Long-Term Safety of Recombinant Human Growth Hormone in Children

Long-term safety of recombinant human growth hormone in children.

BACKGROUND Between 1985 and 2006, the National Cooperative Growth Study (NCGS) monitored the safety and efficacy of recombinant human growth hormone (rhGH) in 54,996 children. METHODS Enrolled patients were followed until rhGH discontinuation. Investigators submitted adverse event reports for targeted events or those potentially rhGH-related. RESULTS Early concerns about de novo leukemia in...

Safety and effectiveness of recombinant human growth hormone replacement in postoperative craniopharyngioma children

Subjects and methods We reviewed the records for all patients undergoing GHRT at our hospital over the study period. Patients were included if they had received CP resection, GHRT for at least 12 months, and records of serial magnetic resonance imaging data and data for treatment, pituitary hormone profiles and growth chart were available. GHnaïve control patients were selected from our hospita...

Long-term efficacy of recombinant human growth hormone therapy in short-statured patients with Noonan syndrome.

PURPOSE Noonan syndrome (NS) is characterized by short stature, heart anomalies, developmental delays, dysmorphic features, cryptorchidism, and coagulation defects. Several studies reported the short-term effects of recombinant human growth hormone (rhGH) treatment on the improvement of height. This study was performed to evaluate the long-term efficacy of rhGH in children with NS in Korea. M...

Recombinant human growth hormone treatment for dilated cardiomyopathy in children.

OBJECTIVE Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure among children and is often progressive despite maximal medical therapy. Heart failure is characterized by a number of neurohormonal abnormalities, including derangements in the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) signaling axis. Decreased serum levels of GH, which acts on cardiac myocy...

Evaluation of Heat Induction Strategy for Recombinant Human Growth Hormone Expression in Fed-Batch Fermentation